Long-term psychological consequences of stroke (OX-CHRONIC): a longitudinal study of cognition in relation to mood and fatigue after stroke: protocol

Demeyere, N; Williams, OA; Milosevich, E; Chiu, EG; Drozdowska, BA; Dillon, A; Dawes, H; Thomas, S; Kuppuswamy, A; Pendlebury, ST; J Quinn, T

Neuroscience & Neuroimaging Research Collection

Journal article

Long-term psychological consequences of stroke (OX-CHRONIC): a longitudinal study of cognition in relation to mood and fatigue after stroke: protocol

Abstract:: Background
The long-term psychological consequences of stroke and how cognitive problems change over time after the first-year following stroke remain unclear. Particularly, trajectories of domain-specific and domain-general cognitive functions and how cognition interacts with mood, fatigue and quality of life are not well described.
Aims
To determine the prevalence, trajectories and wider impact of domain-specific cognitive impairment in long-term stroke survivors, in relation to mood, fatigue and quality of life.
Methods
Participants who previously took part in the Oxford Cognitive Screening study, completed the 6-month follow-up with cognitive, mood, fatigue and quality of life assessments and agreed to be contacted for future research will be recruited into OX-CHRONIC. The eligible cohort is between 2- and 9-years post-stroke. Cognition will be assessed with a detailed neuropsychological battery, alongside questionnaire measures of mood, fatigue, activities of daily life and quality of life measures at two timepoints, 1 year apart. Additionally, medical records will be accessed to extract further clinical information about the stroke and patients may opt-in to wear an activity monitor for 1 week to provide fine-grained measures of sleep and activity. The study protocol and study materials were approved by the national ethics committee (REC Ref: 19/SC/0520).
Planned outputs
OX-CHRONIC will provide detailed data on the evolving cognitive profiles of stroke survivors over several years post-stroke. Estimates of long-term prevalence as well as the effect of changes in cognitive profiles on mood, fatigue and quality of life will be examined. This study is funded by a Priority Programme Grant from the Stroke Association (SA PPA 18/100032).

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Demeyere, N., Williams, O. A., Milosevich, E., Chiu, E. G., Drozdowska, B. A., Dillon, A., Dawes, H., Thomas, S., Kuppuswamy, A., Pendlebury, S. T., & J Quinn, T. (2021). Long-term psychological consequences of stroke (OX-CHRONIC): a longitudinal study of cognition in relation to mood and fatigue after stroke: protocol. European Stroke Journal, 6(4), 428–437.

MLA Style

Demeyere, N, et al. “Long-Term Psychological Consequences of Stroke (OX-CHRONIC): a Longitudinal Study of Cognition in Relation to Mood and Fatigue after Stroke: Protocol.” European Stroke Journal, vol. 6, no. 4, 2021, pp. 428–37.

Chicago Style

Demeyere, N, OA Williams, E Milosevich, et al. 2021. “Long-Term Psychological Consequences of Stroke (OX-CHRONIC): a Longitudinal Study of Cognition in Relation to Mood and Fatigue after Stroke: Protocol.” European Stroke Journal 6 (4): 428–37.
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