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Modification of the release characteristics of estradiol encapsulated in PLGA particles via surface coating.

Abstract:

BACKGROUND: Drug-loaded poly(lactide-co-glycolide) particles (100-4500 nm in diameter) were prepared via the electrospraying method. An extensive study was then carried out to determine the parameters affecting the release profile of estradiol (the drug or active pharmaceutical ingredient) in order to facilitate minimum initial burst release of estradiol. RESULTS AND DISCUSSION: The three most important factors affecting estradiol release were identified as: particle size, coating of the par...

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Publisher copy:
10.4155/tde.11.154

Authors


Enayati, M More by this author
Edirisinghe, M More by this author
Bonfield, W More by this author
Journal:
Therapeutic delivery
Volume:
3
Issue:
2
Pages:
209-226
Publication date:
2012-02-05
DOI:
EISSN:
2041-6008
ISSN:
2041-5990
URN:
uuid:8dbedc2a-281c-42ed-9ca6-bf63e26b98cc
Source identifiers:
327788
Local pid:
pubs:327788

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