Journal article
Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines
- Abstract:
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Background: A and B rings of the steroidal microtubule disruptor, 2-methoxyestradiol, and its analogs can be mimicked with a tetrahydroisoquinoline (THIQ) core. THIQs are cytotoxic agents with potential anticancer activities. The aim of this in vitro study was to investigate the modes of cell death induced by four nonsteroidal THIQ-based analogs, such as STX 2895, STX 3329, STX 3451 and STX 3450, on MDA-MB-231 metastatic breast and A549 epithelial lung carcinoma cells.
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Wellcome Trust
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Funding agency for:
Potter, B
Grant:
Senior Investigator (grant 101010
Medical Research Council of South Africa
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Struwig-Germeshuysen Cancer Research
Trust of South Africa
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National Research Foundation
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Cancer
Association of South Africa
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Bibliographic Details
- Publisher:
- Dove Medical Press Publisher's website
- Journal:
- Drug Design, Development and Therapy Journal website
- Volume:
- 2018:12
- Pages:
- 1881—1904
- Publication date:
- 2018-06-25
- Acceptance date:
- 2018-03-27
- DOI:
- ISSN:
-
1177-8881
Item Description
- Keywords:
- Pubs id:
-
pubs:831923
- UUID:
-
uuid:8db3edea-ae43-40c7-9d22-0905bfb65218
- Local pid:
- pubs:831923
- Source identifiers:
-
831923
- Deposit date:
- 2018-04-20
Terms of use
- Copyright holder:
- Nel et al
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 Nel et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php
and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you
hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
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