Adequate sample size for developing prediction models was not simply related to events per variable.
The choice of an adequate sample size for a Cox regression analysis is generally based on the rule of thumb derived from simulation studies (Peduzzi et al. (1995)) of a minimum of 10 events per variable (EPV). One simulation study suggested scenarios in which the 10 EPV rule can be relaxed (Vittinghoff and McCulloch (2007)). The effect of a range of binary predictors with varying prevalence, reflecting clinical practice, has not yet been fully investigated.We conducted an extended resampling ...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 1.5MB)
- Publisher copy:
- Copyright holder:
- Ogundimu et al
- Copyright date:
- Copyright 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record