Journal article : Comment
Nuisance mediators and missing data in mediation analyses of pain trials
- Abstract:
- This journal recently published a paper by O'Neill and colleagues, entitled "Examining what factors mediate treatment effect in chronic low back pain: a mediation analysis of a Cognitive Functional Therapy clinical trial” (O’Neill, O’Sullivan, O’Sullivan, Purtill, & O’Keeffe, 2020). Although the limitations in O'Neill et al. preclude robust conclusions about the mechanisms of Cognitive Functional Therapy (CFT), their study highlights wider issues for understanding treatment mechanisms for chronic pain. This commentary focuses on two issues: the need for mediation analyses to explain why treatments do not work, and the misreporting of missing data in mediation analyses.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
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(Preview, Accepted manuscript, 155.7KB, Terms of use)
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- Publisher copy:
- 10.1002/ejp.1637
Authors
- Publisher:
- Wiley
- Journal:
- European Journal of Pain More from this journal
- Volume:
- 24
- Issue:
- 9
- Pages:
- 1651-1652
- Publication date:
- 2020-08-20
- Acceptance date:
- 2020-07-22
- DOI:
- EISSN:
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1532-2149
- ISSN:
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1090-3801
- Language:
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English
- Keywords:
- Subtype:
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Comment
- Pubs id:
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1120644
- Local pid:
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pubs:1120644
- Deposit date:
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2020-07-22
Terms of use
- Copyright holder:
- European Pain Federation - EFIC ®
- Copyright date:
- 2020
- Rights statement:
- © 2020 European Pain Federation - EFIC ®
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Wiley at https://doi.org/10.1002/ejp.1637
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