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TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism

Abstract:

The aryl hydrocarbon receptor (AHR) is a transcription factor activated by ligand highly expressed on TH17 cells, and AHR-deficient CD4+ T cells have impaired production of IL-17A and IL-22. Although AHR activation can exacerbate in vivo TH17 cell-mediated autoimmunity, accumulating data indicate that AHR is a nonpathogenic TH17 marker. Thus it remains unclear how AHR activation is regulated and impacts on the generation of TH17 subsets. Here we demonstrated that AHR pathway is activated duri...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41419-018-1107-7

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
Role:
Author
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Grant:
2013/04942-0 and 2016/05013-1
Publisher:
Springer Nature Publisher's website
Journal:
Cell Death and Disease Journal website
Volume:
9
Pages:
Article: 1130
Publication date:
2018-11-13
Acceptance date:
2018-06-25
DOI:
ISSN:
2041-4889
Pubs id:
pubs:944066
URN:
uri:8d826838-cab2-4fef-a0b3-fc52729d8f02
UUID:
uuid:8d826838-cab2-4fef-a0b3-fc52729d8f02
Local pid:
pubs:944066

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