Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.

Journal article

Fibroblast growth factors (FGFs) are a large family of structurally related proteins with a wide range of physiological and pathological activities. Signal transduction requires association of FGF with its receptor tyrosine kinase (FGFR) and heparan sulphate proteoglycan in a specific complex on the cell surface. Direct involvement of the heparan sulphate glycosaminoglycan polysaccharide in the molecular association between FGF and its receptor is essential for biological activity. Although c...

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Authors: Pellegrini, L; Burke, D; von Delft, F; Mulloy, B; Blundell, T

• Publication status: Published
• Journal: Nature
• Volume: 407
• Issue: 6807
• Pages: 1029-1034
• Publication date: 2000-10-01
• DOI: 10.1038/35039551
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Receptors, Fibroblast Growth Factor; Fibroblast Growth Factor 2; Molecular Sequence Data; Humans; Protein Binding; Heparin; Escherichia coli; Recombinant Proteins; Crystallography, X-Ray; Protein Structure, Tertiary; Ligands; Binding Sites; Protein Conformation; Models, Molecular; Fibroblast Growth Factor 1; Receptor Protein-Tyrosine Kinases; Macromolecular Substances; Amino Acid Sequence; Receptor, Fibroblast Growth Factor, Type 2