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Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.

Abstract:

Fibroblast growth factors (FGFs) are a large family of structurally related proteins with a wide range of physiological and pathological activities. Signal transduction requires association of FGF with its receptor tyrosine kinase (FGFR) and heparan sulphate proteoglycan in a specific complex on the cell surface. Direct involvement of the heparan sulphate glycosaminoglycan polysaccharide in the molecular association between FGF and its receptor is essential for biological activity. Although c...

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Publication status:
Published

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Publisher copy:
10.1038/35039551

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
Nature More from this journal
Volume:
407
Issue:
6807
Pages:
1029-1034
Publication date:
2000-10-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836

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