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The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis

Abstract:

Background:To investigate small-nucleolar RNAs (snoRNAs) as reference genes when measuring miRNA expression in tumour samples, given emerging evidence for their role in cancer.Methods:Four snoRNAs, commonly used for normalisation, RNU44, RNU48, RNU43 and RNU6B, and miRNA known to be associated with pathological factors, were measured by real-time polymerase chain reaction in two patient series: 219 breast cancer and 46 head and neck squamous cell carcinoma (HNSCC). SnoRNA and miRNA were then ...

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Publisher copy:
10.1038/sj.bjc.6606076

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Journal:
British Journal of Cancer More from this journal
Volume:
104
Issue:
7
Pages:
1168-1177
Publication date:
2011-03-29
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
pubs:135221
UUID:
uuid:8d4686c4-4618-4a1c-b526-6716a42e45c7
Local pid:
pubs:135221
Source identifiers:
135221
Deposit date:
2012-12-19

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