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Recoupling the cardiac nitric oxide synthases: Tetrahydrobiopterin synthesis and recycling

Abstract:

Nitric oxide (NO), a key regulator of cardiovascular function, is synthesized from L-arginine and oxygen by the enzyme nitric oxide synthase (NOS). This reaction requires tetrahydrobiopterin (BH4) as a cofactor. BH4 is synthesized from guanosine triphosphate (GTP) by GTP cyclohydrolase I (GTPCH) and recycled from 7,8-dihydrobiopterin (BH2) by dihydrofolate reductase. Under conditions of low BH4 bioavailability relative to NOS or BH2, oxygen activation is "uncoupled" from L-arginine oxidation,...

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Publisher copy:
10.1007/s11897-012-0097-5

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Role:
Author
Journal:
Current Heart Failure Reports
Volume:
9
Issue:
3
Pages:
200-210
Publication date:
2012-09-01
DOI:
EISSN:
1546-9549
ISSN:
1546-9530
URN:
uuid:8d2e3442-878c-4856-a519-e65cf5f4e936
Source identifiers:
377645
Local pid:
pubs:377645

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