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Is sensitization with nicotinamide and carbogen dependent on nicotinamide concentration at the time of irradiation?

Abstract:

PURPOSE: To determine whether tumour radiosensitization and the therapeutic benefit of administering carbogen with nicotinamide depend upon irradiating at the time of peak drug concentration. MATERIALS AND METHODS: Local tumour control of CaNT tumours in CBA mice and acute skin reactions in albino WHT mice were assessed after treatment with 10 X-ray fractions in air, carbogen alone or combined with 0.1, 0.2 or 0.5 mg g(-1) nicotinamide, injected 15, 30 or 60 min before irradiation. Plasma and...

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Publication status:
Published

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Journal:
International journal of radiation biology More from this journal
Volume:
80
Issue:
7
Pages:
499-506
Publication date:
2004-07-01
DOI:
EISSN:
1362-3095
ISSN:
0955-3002
Language:
English
Keywords:
Pubs id:
pubs:131800
UUID:
uuid:8d2095aa-be75-4428-97cd-e287e8fc4ea6
Local pid:
pubs:131800
Source identifiers:
131800
Deposit date:
2013-11-17

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