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Inositol hexakisphosphate increases the size of platelet aggregates

Abstract:

The inositol phosphates, InsP5 and InsP6, have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. Here, we investigated the putative physiological role of this interaction and found that platelets increase their InsP6 concentration upon stimulation with the PLC-activating agonists thrombin, collagen I and ADP and present a fraction of it at the outer plasma membrane. Cone and ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.bcp.2018.12.011

Authors


Rehbach, C More by this author
Erdmann, N More by this author
Kolšek, K More by this author
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Funding agency for:
Potter, BVL
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biochemical Pharmacology Journal website
Volume:
161
Pages:
14-25
Publication date:
2018-12-14
Acceptance date:
2018-12-13
DOI:
EISSN:
1873-2968
ISSN:
0006-2952
Pubs id:
pubs:953010
URN:
uri:8d0daa9c-66f9-4822-ac7d-46432c312f5b
UUID:
uuid:8d0daa9c-66f9-4822-ac7d-46432c312f5b
Local pid:
pubs:953010

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