Journal article
Inositol hexakisphosphate increases the size of platelet aggregates
- Abstract:
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The inositol phosphates, InsP5 and InsP6, have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. Here, we investigated the putative physiological role of this interaction and found that platelets increase their InsP6 concentration upon stimulation with the PLC-activating agonists thrombin, collagen I and ADP and present a fraction of it at the outer plasma membrane. Cone and ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
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(pdf, 7.7MB)
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- Publisher copy:
- 10.1016/j.bcp.2018.12.011
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Biochemical Pharmacology Journal website
- Volume:
- 161
- Pages:
- 14-25
- Publication date:
- 2018-12-14
- Acceptance date:
- 2018-12-13
- DOI:
- EISSN:
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1873-2968
- ISSN:
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0006-2952
- Pubs id:
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pubs:953010
- URN:
-
uri:8d0daa9c-66f9-4822-ac7d-46432c312f5b
- UUID:
-
uuid:8d0daa9c-66f9-4822-ac7d-46432c312f5b
- Local pid:
- pubs:953010
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- Elsevier Inc.
- Copyright date:
- 2018
- Notes:
- Crown Copyright © 2018 Published by Elsevier Inc. This is an open access article under the CC BY license.
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