Journal article
Inositol hexakisphosphate increases the size of platelet aggregates
- Abstract:
-
The inositol phosphates, InsP5 and InsP6, have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. Here, we investigated the putative physiological role of this interaction and found that platelets increase their InsP6 concentration upon stimulation with the PLC-activating agonists thrombin, collagen I and ADP and present a fraction of it at the outer plasma membrane. Cone and ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(pdf, 7.7MB)
-
- Publisher copy:
- 10.1016/j.bcp.2018.12.011
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Wellcome Trust
More from this funder
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Biochemical Pharmacology Journal website
- Volume:
- 161
- Pages:
- 14-25
- Publication date:
- 2018-12-14
- Acceptance date:
- 2018-12-13
- DOI:
- EISSN:
-
1873-2968
- ISSN:
-
0006-2952
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:953010
- UUID:
-
uuid:8d0daa9c-66f9-4822-ac7d-46432c312f5b
- Local pid:
- pubs:953010
- Deposit date:
- 2018-12-17
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2018
- Notes:
- Crown Copyright © 2018 Published by Elsevier Inc. This is an open access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record