Journal article
PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
- Abstract:
-
PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods. Here, we utilised an improved antibody to detect mono-ADP-ribosylation. We visualised endogenous interferon (IFN)-induced ADP-ribosylation and show that PARP14 is a major enzyme responsible for this modification. Fittingly, this signalling is reversed by the macrodomain from ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/s44318-024-00126-0
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Bibliographic Details
- Publisher:
- EMBO Press
- Journal:
- The EMBO Journal More from this journal
- Volume:
- 43
- Issue:
- 14
- Pages:
- 2929-2953
- Publication date:
- 2024-06-04
- Acceptance date:
- 2024-05-08
- DOI:
- EISSN:
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1460-2075
Item Description
- Language:
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English
- Keywords:
- Source identifiers:
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2110821
- Deposit date:
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2024-07-15
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