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A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination

Abstract:

During meiotic recombination in most mammals, hundreds of programmed DNA Double-Strand Breaks (DSBs) occur across all chromosomes in each cell at sites bound by the protein PRDM9. Faithful DSB repair using the homologous chromosome is essential for fertility, yielding either non-crossovers, which are frequent but difficult to detect, or crossovers. In certain hybrid mice, high sequence divergence causes PRDM9 to bind each homologue at different sites, 'asymmetrically', and these mice exhibit ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-11675-y

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Oxford college:
Somerville College
Role:
Author
ORCID:
0000-0003-4095-424X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Wellcome Trust Centre for Human Genetics
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0002-7231-6026
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Wellcome Trust Centre for Human Genetics
Role:
Author
ORCID:
0000-0003-3623-600X
More from this funder
Name:
Wellcome Trust
Grant:
098387/Z/12/Z
212284/Z/18/Z
Publisher:
Nature Research
Journal:
Nature Communications More from this journal
Volume:
10
Article number:
3900
Publication date:
2019-08-29
Acceptance date:
2019-07-17
DOI:
EISSN:
2041-1723
Keywords:
Pubs id:
pubs:930944
UUID:
uuid:8d09869a-0c99-46dc-977a-6704294667b6
Local pid:
pubs:930944
Source identifiers:
930944
Deposit date:
2019-08-19

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