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L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease.

Abstract:

Diminished levels of L-arginine and endothelial nitric oxide synthase (eNOS) uncoupling through deficiency of tetrahydrobiopterin (BH(4)) may contribute to endothelial dysfunction. We investigated the effect of L-arginine and BH(4) administration on ischemia-reperfusion (I/R)-induced endothelial dysfunction in patients with type 2 diabetes and coronary artery disease (CAD). Forearm blood flow was measured by venous occlusion plethysmography in 12 patients with type 2 diabetes or impaired gluc...

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Publication status:
Published

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Authors


Settergren, M More by this author
Malmström, RE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Atherosclerosis
Volume:
204
Issue:
1
Pages:
73-78
Publication date:
2009-05-05
DOI:
EISSN:
1879-1484
ISSN:
0021-9150
URN:
uuid:8d08192e-0b80-48d3-a2ab-ddb64b2b939f
Source identifiers:
105307
Local pid:
pubs:105307

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