Damage segregation at fissioning may increase growth rates: a superprocess model.

Journal article

Abstract:: A fissioning organism may purge unrepairable damage by bequeathing it preferentially to one of its daughters. Using the mathematical formalism of superprocesses, we propose a flexible class of analytically tractable models that allow quite general effects of damage on death rates and splitting rates and similarly general damage segregation mechanisms. We show that, in a suitable regime, the effects of randomness in damage segregation at fissioning are indistinguishable from those of randomnes...
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Role:

Author

Institution:

University of Oxford

Division:

MPLS

Department:

Statistics

Role:

Author

Language:: English
Keywords:: Models, Statistical

Cell Survival

Escherichia coli

Models, Biological

DNA Damage
Pubs id:: pubs:97721
UUID:: uuid:8cfbc367-b340-4f9d-a984-7d0cb6c04963
Local pid:: pubs:97721
Source identifiers:: 97721
Deposit date:: 2012-12-19

Notes:: Version 2 had significant conceptual and organizational changes,
though only minor changes to the mathematics. Version 3 has minor
proofreading corrections, and a few new references. The paper will appear in
Theoretical Population Biology

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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