Journal article
Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
- Abstract:
-
Two isoforms of the enzyme 11beta-hydroxysteroid dehydrogenase (11beta-HSD) interconvert the active glucocorticoid, cortisol, and inactive cortisone. 11beta-HSD1 is believed to act in vivo predominantly as an oxo-reductase using NADP(H) as a cofactor to generate cortisol. In contrast, 11beta-HSD2 acts exclusively as an NAD-dependent dehydrogenase inactivating cortisol to cortisone, thereby protecting the mineralocorticoid receptor from occupation by cortisol. In peripheral tissues, both enzym...
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- Publication status:
- Published
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- Publisher copy:
- 10.1053/beem.2000.0119
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Authors
Bibliographic Details
- Journal:
- Best practice and research. Clinical endocrinology and metabolism
- Volume:
- 15
- Issue:
- 1
- Pages:
- 61-78
- Publication date:
- 2001-03-01
- DOI:
- EISSN:
-
1878-1594
- ISSN:
-
1521-690X
- Source identifiers:
-
482112
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:482112
- UUID:
-
uuid:8cfa0d0f-8998-44d7-a462-63345e466712
- Local pid:
- pubs:482112
- Deposit date:
- 2014-08-29
Terms of use
- Copyright date:
- 2001
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