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Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.

Abstract:

Two isoforms of the enzyme 11beta-hydroxysteroid dehydrogenase (11beta-HSD) interconvert the active glucocorticoid, cortisol, and inactive cortisone. 11beta-HSD1 is believed to act in vivo predominantly as an oxo-reductase using NADP(H) as a cofactor to generate cortisol. In contrast, 11beta-HSD2 acts exclusively as an NAD-dependent dehydrogenase inactivating cortisol to cortisone, thereby protecting the mineralocorticoid receptor from occupation by cortisol. In peripheral tissues, both enzym...

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Publication status:
Published

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Publisher copy:
10.1053/beem.2000.0119

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Role:
Author
Journal:
Best practice and research. Clinical endocrinology and metabolism
Volume:
15
Issue:
1
Pages:
61-78
Publication date:
2001-03-05
DOI:
EISSN:
1878-1594
ISSN:
1521-690X
URN:
uuid:8cfa0d0f-8998-44d7-a462-63345e466712
Source identifiers:
482112
Local pid:
pubs:482112

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