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Phase 1 evaluation of 3 highly immunogenic prime-boost regimens, including a 12-month reboosting vaccination, for malaria vaccination in Gambian men.

Abstract:

Successful vaccination against intracellular pathogens, including liver-stage Plasmodium falciparum, will require induction of strong antigen-specific T lymphocyte responses. The multiple epitope (ME)-thrombospondin-related adhesion protein (TRAP) construct includes CD8(+) and CD4(+) T cell epitopes from pre-erythrocytic P. falciparum antigens fused in-frame to the entire pre-erythrocytic antigen TRAP. Three carriers for this construct--plasmid DNA and 2 recombinant nonreplicating poxviruses ...

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Publication status:
Published

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Publisher copy:
10.1086/421118

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Volume:
189
Issue:
12
Pages:
2213-2219
Host title:
The Journal of infectious diseases
Publication date:
2004-06-01
Event location:
United States
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Source identifiers:
39094

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