Journal article
Clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment
- Abstract:
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Background: Despite the wide array of treatments available for rheumatoid arthritis (RA), some patients continue to report unmet clinical needs. We investigated the extent of inadequate disease control in patients with RA.
Methods: Data were drawn from the Adelphi 2014 RA Disease Specific Program in France, Germany, Italy, Spain and the UK. Rheumatologists provided patient demographics, comorbidities, satisfaction with RA control and other clinical details. Patients reported their level of satisfaction and completed the EuroQoL 5-Dimensions health questionnaire and Work Productivity and Activity Impairment questionnaire. Patients had been on their current therapy ≥3 months and had 28-joint disease activity scores (DAS28) reported. Adequately controlled (DAS28 ≤3.2) and inadequately controlled (DAS28 >3.2) patient cohorts were compared using univariate tests.
Results: Of 1147 patients, 74% were female, the mean age was 52 years and the mean time since RA diagnosis was 7 years. Twenty-seven percent of patients had inadequately controlled RA whereas 73% had adequately controlled RA. Inadequately controlled patients were more affected clinically versus adequately controlled patients; 69% versus 13% had moderate/severe RA, the current level of pain was 4.6 versus 2.3, and 67% versus 41% experienced flares, respectively (all p<0.0001). Inadequately controlled patients had higher rates of depression (16% versus 5%; p<0.0001), worse health state, greater work and activity impairment, and lower satisfaction rates among the patients and their physicians than the adequately controlled cohort.
Conclusion: RA was insufficiently controlled in over a quarter of patients despite their current therapy and this had a negative impact on the patients.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 636.3KB, Terms of use)
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- Publisher copy:
- 10.1136/rmdopen-2017-000615
Authors
- Publisher:
- BMJ Publishing Group
- Journal:
- RMD Open More from this journal
- Volume:
- 4
- Issue:
- 1
- Pages:
- e000615
- Publication date:
- 2018-03-17
- Acceptance date:
- 2018-02-26
- DOI:
- ISSN:
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2056-5933
- Keywords:
- Pubs id:
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pubs:827143
- UUID:
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uuid:8cec3cdd-325b-4111-8ada-6d883fb7a1cf
- Local pid:
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pubs:827143
- Source identifiers:
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827143
- Deposit date:
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2018-03-01
Terms of use
- Copyright holder:
- © Taylor, et al (or their employer(s) unless otherwise stated in the text of the article) 2018 All rights reserved
- Copyright date:
- 2018
- Notes:
- This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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