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Prescribed opioid analgesic use in pregnancy and risk of neurodevelopmental disorders in children: A retrospective study in Sweden

Abstract:

Background: The extent to which the documented association between prenatal prescribed opioid analgesic (POA) exposure and neurodevelopmental disorders in children is causal or due to confounding is unknown. The objective of this study was to evaluate associations between dose and duration of POA exposure during pregnancy and autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD) in children while minimizing bias due to confounding and other sources. Methods and fin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.1004721

Authors


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Role:
Author
ORCID:
0000-0001-6929-544X
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Role:
Author
ORCID:
0000-0002-4374-9949
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Role:
Author
ORCID:
0009-0005-8655-6505
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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Sub department:
Psychiatry
Role:
Author


Publisher:
Public Library of Science
Journal:
PLoS Medicine More from this journal
Volume:
22
Issue:
9
Article number:
e1004721
Publication date:
2025-09-16
Acceptance date:
2025-08-08
DOI:
EISSN:
1549-1676
ISSN:
1549-1277


Language:
English
Source identifiers:
3288108
Deposit date:
2025-09-16
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