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Occult HIV-1 drug resistance to thymidine analogues following failure of first-line tenofovir combined with a cytosine analogue and nevirapine or efavirenz in sub Saharan Africa: a retrospective multi-centre cohort study

Abstract:

Background

HIV-1 drug resistance to older thymidine analogue nucleoside reverse transcriptase inhibitor drugs has been identified in sub-Saharan Africa in patients with virological failure of first-line combination antiretroviral therapy (ART) containing the modern nucleoside reverse transcriptase inhibitor tenofovir. We aimed to investigate the prevalence and correlates of thymidine analogue mutations (TAM) in patients with virological failure of first-line tenofovir-containing ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Elsevier
Journal:
Lancet Infectious Diseases More from this journal
Volume:
17
Issue:
3
Pages:
296-304
Publication date:
2016-12-01
DOI:
ISSN:
1474-4457 and 1473-3099
Keywords:
Pubs id:
pubs:699712
UUID:
uuid:8caf9933-3d0a-4c74-8e30-570e5636d9b7
Local pid:
pubs:699712
Source identifiers:
699712
Deposit date:
2017-06-14

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