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HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective.

Abstract:

BACKGROUND: Human leukocyte allele (HLA) class I polymorphism has the greatest impact of human genetic variation on viral load set point. A substantial part of this effect is due to the action of HLA-B and HLA-C alleles. With few exceptions the role of HLA-A molecules in immune control of HIV is unclear. METHODS: We here study HLA-A*68:02, one of the most highly prevalent HLA-A alleles in C-clade infected sub-Saharan African populations, and one that plays a prominent role in the HIV-specifi...

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Publication status:
Published

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Journal:
AIDS (London, England)
Volume:
27
Issue:
11
Pages:
1717-1723
Publication date:
2013-07-01
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Source identifiers:
390905
Language:
English
Keywords:
Pubs id:
pubs:390905
UUID:
uuid:8c8fe1d7-6435-424b-a04c-0217038fe519
Local pid:
pubs:390905
Deposit date:
2013-11-16

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