Journal article
HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective.
- Abstract:
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BACKGROUND: Human leukocyte allele (HLA) class I polymorphism has the greatest impact of human genetic variation on viral load set point. A substantial part of this effect is due to the action of HLA-B and HLA-C alleles. With few exceptions the role of HLA-A molecules in immune control of HIV is unclear. METHODS: We here study HLA-A*68:02, one of the most highly prevalent HLA-A alleles in C-clade infected sub-Saharan African populations, and one that plays a prominent role in the HIV-specifi...
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- Publication status:
- Published
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- Publisher copy:
- 10.1097/qad.0b013e32836146cd
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Bibliographic Details
- Journal:
- AIDS (London, England)
- Volume:
- 27
- Issue:
- 11
- Pages:
- 1717-1723
- Publication date:
- 2013-07-01
- DOI:
- EISSN:
-
1473-5571
- ISSN:
-
0269-9370
- Source identifiers:
-
390905
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:390905
- UUID:
-
uuid:8c8fe1d7-6435-424b-a04c-0217038fe519
- Local pid:
- pubs:390905
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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