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Immunity promotes virulence evolution in a malaria model

Abstract:

Evolutionary models predict that host immunity will shape the evolution of parasite virulence. While some assumptions of these models have been tested, the actual evolutionary outcome of immune selection on virulence has not. Using the mouse malaria model, Plasmodium chabaudi, we experimentally tested whether immune pressure promotes the evolution of more virulent pathogens by evolving parasite lines in immunized and nonimmunized ("naïve") mice using serial passage. We found that parasite lin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pbio.0020230

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Biology More from this journal
Publication date:
2004-06-22
Acceptance date:
2004-05-25
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Language:
English
Keywords:
UUID:
uuid:8c746502-517c-4796-9a65-6a1e6f78706d
Local pid:
pubs:90490
Source identifiers:
90490
Deposit date:
2012-12-19

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