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The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.

Abstract:
Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.
Publication status:
Published

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Publisher copy:
10.1038/nsmb1216

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Nature structural and molecular biology More from this journal
Volume:
14
Issue:
4
Pages:
341-343
Publication date:
2007-04-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Language:
English
Keywords:
Pubs id:
pubs:99800
UUID:
uuid:8c649194-70a8-40a3-9f9f-3fe102d62145
Local pid:
pubs:99800
Source identifiers:
99800
Deposit date:
2012-12-19

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