The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.

Journal article

Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.

Authors: Lee, N; Zhang, J; Klose, R; Erdjument-Bromage, H; Tempst, P

• Publication status: Published
• Journal: Nature structural and molecular biology
• Volume: 14
• Issue: 4
• Pages: 341-343
• Publication date: 2007-04-01
• DOI: 10.1038/nsmb1216
• EISSN: 1545-9985
• ISSN: 1545-9993
• Language: English
• Keywords: RNA Polymerase II; Lysine; Drosophila melanogaster; Drosophila Proteins; Larva; Animals; Histones; Transcription Factors; Substrate Specificity; Methylation; Histone-Lysine N-Methyltransferase; Protein Transport; Protein Structure, Tertiary; DNA-Binding Proteins; Mutant Proteins