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Extracellularly applied ruthenium red and cADP ribose elevate cytosolic Ca2+ in isolated rat osteoclasts

Abstract:

We demon-strated recently that the divalent cation-sensing receptor on the osteoclast, the Ca2+ receptor (CaR), is a functional component of a cell surface-expressed ryanodine receptor-like molecule (RyR). The objective of the present study was to further characterize this putative RyR by use of the two well-known cell-impermeant RyR modulators, ruthenium red and adenosine 3′,5′-cyclic diphosphate ribose (cADPr). We found that, when applied extracellularly, ruthenium red (5 × 10-8-10-4 M) and...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
American Journal of Physiology
Volume:
270
Issue:
3 PART 2
Publication date:
1996-01-01
ISSN:
0002-9513
URN:
uuid:8c50b427-ea13-4647-911d-51c3ce6a665d
Source identifiers:
475728
Local pid:
pubs:475728
Language:
English
Keywords:

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