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Journal article

Diverse mechanisms of IRF5 action in inflammatory responses

Abstract:

Interferon regulatory factor 5 (IRF5) is a key signal-dependent transcription factor in myeloid cells. Its expression is induced by granulocyte-macrophage colony stimulating factor and interferon-gamma. IRF5 protein is further activated in response to stimulation, translocating to the nucleus where it mediates inflammatory responses. IRF5 is capable of both the up-regulation of pro-inflammatory genes and repressing anti-inflammatory mediators, thus polarising macrophages to a pro-inflammatory...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.biocel.2018.03.012

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Name:
Kennedy Institute Trustees’ Research Fund
Publisher:
Elsevier
Journal:
International Journal of Biochemistry and Cell Biology More from this journal
Volume:
99
Pages:
38-42
Publication date:
2018-03-22
Acceptance date:
2018-03-12
DOI:
EISSN:
1878-5875
ISSN:
1357-2725
Keywords:
Pubs id:
pubs:856434
UUID:
uuid:8c4a051d-7756-4a2f-946e-53eecad6c59b
Local pid:
pubs:856434
Source identifiers:
856434
Deposit date:
2018-06-08

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