Journal article
Diverse mechanisms of IRF5 action in inflammatory responses
- Abstract:
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Interferon regulatory factor 5 (IRF5) is a key signal-dependent transcription factor in myeloid cells. Its expression is induced by granulocyte-macrophage colony stimulating factor and interferon-gamma. IRF5 protein is further activated in response to stimulation, translocating to the nucleus where it mediates inflammatory responses. IRF5 is capable of both the up-regulation of pro-inflammatory genes and repressing anti-inflammatory mediators, thus polarising macrophages to a pro-inflammatory...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Accepted manuscript, pdf, 1.2MB)
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- Publisher copy:
- 10.1016/j.biocel.2018.03.012
Authors
Funding
Arthritis Research UK
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Kennedy Institute Trustees’ Research Fund
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- International Journal of Biochemistry and Cell Biology Journal website
- Volume:
- 99
- Pages:
- 38-42
- Publication date:
- 2018-03-22
- Acceptance date:
- 2018-03-12
- DOI:
- EISSN:
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1878-5875
- ISSN:
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1357-2725
Item Description
- Keywords:
- Pubs id:
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pubs:856434
- UUID:
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uuid:8c4a051d-7756-4a2f-946e-53eecad6c59b
- Local pid:
- pubs:856434
- Source identifiers:
-
856434
- Deposit date:
- 2018-06-08
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Elsevier Ltd. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.biocel.2018.03.012
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