Thesis
Dynamic combinatorial mass spectrometry for 2-oxoglutarate oxygenase inhibition
- Abstract:
-
In the last decade, dynamic combinatorial mass spectrometry (DCMS) with protein targets has emerged as a promising method for the identification of enzyme-inhibitors. 2-Oxoglutarate (2OG) oxygenases are involved in important biological processes related to many diseases; several human 2OG oxygenases are targeted for pharmaceutical intervention. This thesis describes inhibition studies on three 2OG oxygenases using DCMS and structure activity relation (SAR) studies.
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Authors
Contributors
+ Schofield, C
Division:
MPLS
Department:
History Faculty
Sub department:
Archaeology Research Lab
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:8c3a3a33-bc1a-407e-8b86-70c5eca58f38
- Local pid:
- ora:10094
- Deposit date:
- 2015-02-18
Terms of use
- Copyright holder:
- Dr. Marina Demetriades
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA
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