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Journal article

HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.

Abstract:

Otitis media with effusion (OME) is the commonest cause of hearing loss in children, yet the underlying genetic pathways and mechanisms involved are incompletely understood. Ventilation of the middle ear with tympanostomy tubes is the commonest surgical procedure in children and the best treatment for chronic OME, but the mechanism by which they work remains uncertain. As hypoxia is a common feature of inflamed microenvironments, moderation of hypoxia may be a significant contributory mechani...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1002336

Authors


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Medical Research Council More from this funder
MRC Technology More from this funder
GlaxoSmithKline More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
7
Issue:
10
Pages:
Article: e1002336
Publication date:
2011-10-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:8c3a3646-411c-45ab-b751-77ecd71cb4fc
Source identifiers:
206250
Local pid:
pubs:206250

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