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Safety and immunogenicity of malaria vectored vaccines given with routine EPI vaccines in Gambian infants and neonates: a randomized controlled trial

Abstract:

Background: Heterologous prime-boost vaccination with ChAd63 and MVA encoding ME-TRAP has shown acceptable safety and promising immunogenicity in African adult and pediatric populations. If licensed, this vaccine could be given to infants receiving routine childhood immunizations. We therefore evaluated responses to ChAd63 MVA ME-TRAP when co-administered with routine Expanded Programme on Immunization (EPI) vaccines.

Methods: We enrolled 65 Gambian infants and neonates, a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2017.01551

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
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Swedish International Development Cooperation Agency More from this funder
Irish Aid, Department of Foreign Affairs and Trade, Ireland More from this funder
Bundesministerium für Bildung und Forschung More from this funder
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
8
Issue:
1551
Pages:
1-17
Publication date:
2017-11-20
Acceptance date:
2017-10-31
DOI:
ISSN:
1664-3224
Source identifiers:
739211
Pubs id:
pubs:739211
UUID:
uuid:8c34f703-564b-4fc1-86a9-f226f9a31547
Local pid:
pubs:739211
Deposit date:
2017-10-31

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