Journal article icon

Journal article

ChAd63-MVA-vectored blood-stage Malaria vaccines targeting MSP1 and AMA1: Assessment of efficacy against mosquito bite challenge in humans

Abstract:

The induction of cellular immunity, in conjunction with antibodies, may be essential for vaccines to protect against blood-stage infection with the human malaria parasite Plasmodium falciparum. We have shown that prime-boost delivery of P. falciparum blood-stage antigens by chimpanzee adenovirus 63 (ChAd63) followed by the attenuated orthopoxvirus MVA is safe and immunogenic in healthy adults. Here, we report on vaccine efficacy against controlled human malaria infection delivered by mosquito...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/mt.2012.223

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
Expand authors...
Journal:
Molecular Therapy
Volume:
20
Issue:
12
Pages:
2355-2368
Publication date:
2012-12-01
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:8c183715-30a7-4819-a45c-1e3a738e8d6c
Source identifiers:
368169
Local pid:
pubs:368169

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP