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Journal article

Mutation burden and other molecular markers of prognosis in the QUASAR2 clinical trial of colorectal cancer treated with curative intent

Abstract:

Background

Several relatively large studies have assessed molecular indicators of colorectal cancer (CRC) prognosis, but most analyses have been restricted to a handful of markers.

Methods

In stage II/III CRCs from the QUASAR2 clinical trial and from an Australian community-based series, we assessed gene panels for somatic driver mutations and overall mutation burden. We determined molecular pathways of tumorigenesis, and analysed associations with treatment respo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S2468-1253(18)30117-1

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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UK Technology Strategy Board More from this funder
National Institute for Health Research More from this funder
Cancer Research UK More from this funder
Cancer Australia More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Gastroenterology and Hepatology Journal website
Volume:
3
Issue:
9
Pages:
635-643
Publication date:
2018-07-02
Acceptance date:
2018-03-27
DOI:
EISSN:
2468-1253
Pubs id:
pubs:831869
URN:
uri:8beef45c-b49a-4254-bde3-06b097511a6d
UUID:
uuid:8beef45c-b49a-4254-bde3-06b097511a6d
Local pid:
pubs:831869

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