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Journal article

Target tau, not amyloid, to prevent and treat Alzheimer’s disease

Abstract:

In this article I wish to put the case for a change of emphasis in the approach to finding a prevention/treatment for Alzheimer’s disease from a focus on beta amyloid to one on tau. In particular, I make the case for aiming to prevent the spread of abnormal tau from the medial temporal lobe to widespread areas of association cortex that are anatomically linked to this critical region. I pose an analogy with cardiovascular disease in which the initiating pathology, lipid streaks, are left untr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.21926/obm.geriatr.2001103

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Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Publisher:
LIDSEN Publishing Inc
Journal:
OBM Geriatrics More from this journal
Volume:
4
Issue:
1
Publication date:
2020-02-04
Acceptance date:
2020-01-22
DOI:
ISSN:
2638-1311
Keywords:
Pubs id:
1095832
Local pid:
pubs:1095832
Deposit date:
2020-03-23

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