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Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde

Abstract:

Metampicillin is a β-lactam antibiotic that is prepared by the reaction of ampicillin with formaldehyde. Although metampicillin has been studied for treatment of infections in animals and humans, its structure has been unclear. We report NMR studies revealing that metampicillin contains a formaldehyde-derived cyclic aminal. NMR time-course experiments with excess formaldehyde in solution show formation of another product with an additional exocyclic hemiaminal group formed by reaction with th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-020-74990-1

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0002-0290-6565
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Grant:
MR/P007503/1
MR/L007665/1
Publisher:
Nature Research Publisher's website
Journal:
Scientific Reports Journal website
Volume:
10
Article number:
17955
Publication date:
2020-10-21
Acceptance date:
2020-09-03
DOI:
EISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
1132751
Local pid:
pubs:1132751
Deposit date:
2020-09-18

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