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Vitamin B12

Abstract:

The biosynthesis of B 12 , involving up to 30 different enzyme-mediated steps, only occurs in bacteria. Thus, most eukaryotes require an external source of B 12 , and yet the vitamin appears to have only two functions in eukaryotes: as a cofactor for the enzymes methionine synthase and methylmalonylCoA mutase. These two functions are crucial for normal health in humans, and in particular, the formation of methionine is essential for providing methyl groups for over 100 methylation processes. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/bs.afnr.2017.11.005

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Advances in Food and Nutrition Research Journal website
Volume:
83
Pages:
215-279
Publication date:
2018-02-02
Acceptance date:
2017-10-30
DOI:
ISSN:
1043-4526
Source identifiers:
825471
Keywords:
Pubs id:
pubs:825471
UUID:
uuid:8bd7451a-0ad5-4c58-a55d-1cd8b03c7ec7
Local pid:
pubs:825471
Deposit date:
2018-02-20

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