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Journal article

Hypoxia and myocardial remodeling in human cardiac allografts: a time-course study.

Abstract:

BACKGROUND: Cardiac allografts are known to develop myocardial fibrosis, which may be a cause of progressive cardiac dysfunction. Apart from the renin-angiotensin and transforming growth factor-beta system, hypoxia has been proposed as an important player in the pathogenesis of fibrosis, but its significance remains unclear. This study examines the degree of myocardial fibrosis, cellular remodeling and hypoxic signaling over a time-course of 10 years after human cardiac allograft transplanta...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences
Role:
Author
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Journal:
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Volume:
28
Issue:
11
Pages:
1119-1126
Publication date:
2009-11-05
DOI:
EISSN:
1557-3117
ISSN:
1053-2498
URN:
uuid:8bce8c7f-eef0-4b6f-aa50-0641514a7a2f
Source identifiers:
324075
Local pid:
pubs:324075

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