Journal article icon

Journal article

Phospholipase C zeta and male infertility: clinical update and topical developments

Abstract:

The development of a mammalian embryo is initiated by a sequence of molecular events collectively referred to as ‘oocyte activation’ and regulated by the release of intracellular calcium in the ooplasm. Over the last decade, phospholipase C zeta (PLCζ), a sperm protein introduced into the oocyte upon gamete fusion, has gained almost universal acceptance as the protein factor responsible for initiating oocyte activation. A large body of consistent and reproducible evidence, from both biochemic...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.jbior.2015.11.009

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
More from this funder
Name:
European Commission, FP7-People Programme, Marie Curie-IEF
Grant:
626061
More from this funder
Name:
Universiti Brunei Darussalam.
More from this funder
Name:
Ministry of Education (Brunei Darussalam)
Publisher:
Elsevier
Journal:
Advances in Biological Regulation More from this journal
Volume:
61
Issue:
May 2016
Pages:
58-67
Publication date:
2015-11-30
Acceptance date:
2015-11-26
DOI:
ISSN:
2212-4934
Keywords:
Pubs id:
pubs:580074
UUID:
uuid:8bb0e099-015c-46e8-8347-2bb6c130c9c6
Local pid:
pubs:580074
Source identifiers:
580074
Deposit date:
2015-12-15

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP