- Abstract:
-
Neuromyelitis Optica (NMO) is a severe neuro-inflammatory disease of the central nervous system characterized by predominant damage to the optic nerve and of the spinal cord. The pathogenic antibody found in the majority of patients targets the AQP4 channels on astrocytic endfeet and causes the cells to swell. Although, the pathophysiology of the disease is broadly known, there are no specific targeted treatments for this process clinically available nor accurate prognostic markers both durin...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 594.2KB)
-
(pdf, 879.3KB)
-
- Publisher copy:
- 10.1016/j.jtbi.2017.08.020
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Theoretical Biology Journal website
- Volume:
- 433
- Pages:
- 39-48
- Publication date:
- 2017-08-23
- Acceptance date:
- 2017-08-22
- DOI:
- EISSN:
-
1095-8541
- ISSN:
-
0022-5193
- Pubs id:
-
pubs:725936
- URN:
-
uri:8b9f2497-d4c4-42f8-a012-d7a75b035d6c
- UUID:
-
uuid:8b9f2497-d4c4-42f8-a012-d7a75b035d6c
- Local pid:
- pubs:725936
- Language:
- English
- Keywords:
- Copyright holder:
- Laranjeira et al.
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 Published by Elsevier Ltd. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.jtbi.2017.08.020
Journal article
A mathematical model of cellular swelling in Neuromyelitis optica
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