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A mathematical model of cellular swelling in Neuromyelitis optica

Abstract:

Neuromyelitis Optica (NMO) is a severe neuro-inflammatory disease of the central nervous system characterized by predominant damage to the optic nerve and of the spinal cord. The pathogenic antibody found in the majority of patients targets the AQP4 channels on astrocytic endfeet and causes the cells to swell. Although, the pathophysiology of the disease is broadly known, there are no specific targeted treatments for this process clinically available nor accurate prognostic markers both durin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.jtbi.2017.08.020

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
Keble College
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Journal of Theoretical Biology Journal website
Volume:
433
Pages:
39-48
Publication date:
2017-08-23
Acceptance date:
2017-08-22
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
Pubs id:
pubs:725936
URN:
uri:8b9f2497-d4c4-42f8-a012-d7a75b035d6c
UUID:
uuid:8b9f2497-d4c4-42f8-a012-d7a75b035d6c
Local pid:
pubs:725936

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