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Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4

Abstract:
The mechanistic basis of the marked oxygen sensitivity of glomus cells in the carotid body has long puzzled physiologists. In this issue of Science Signaling, Moreno-Domínguez et al. show the critical importance of high levels of hypoxia-inducible factor, HIF2α/EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxidase subunit, COX4I2, in glomus cell sensitivity to hypoxia.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/scisignal.aba1302

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
Publisher:
American Association for the Advancement of Science
Journal:
Science Signaling More from this journal
Volume:
13
Issue:
615
Article number:
eaba1302
Publication date:
2020-01-21
Acceptance date:
2019-01-02
DOI:
EISSN:
1937-9145
ISSN:
1945-0877
Language:
English
Pubs id:
1084208
Local pid:
pubs:1084208
Deposit date:
2020-01-31

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