Journal article
Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4
- Abstract:
- The mechanistic basis of the marked oxygen sensitivity of glomus cells in the carotid body has long puzzled physiologists. In this issue of Science Signaling, Moreno-Domínguez et al. show the critical importance of high levels of hypoxia-inducible factor, HIF2α/EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxidase subunit, COX4I2, in glomus cell sensitivity to hypoxia.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Signaling Journal website
- Volume:
- 13
- Issue:
- 615
- Article number:
- eaba1302
- Publication date:
- 2020-01-21
- Acceptance date:
- 2019-01-02
- DOI:
- EISSN:
-
1937-9145
- ISSN:
-
1945-0877
Item Description
- Language:
- English
- Pubs id:
-
1084208
- Local pid:
- pubs:1084208
- Deposit date:
- 2020-01-31
Terms of use
- Copyright holder:
- Bishop and Ratcliffe
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
- Notes:
- This is the accepted manuscript version of the article. The final version is available from American Association for the Advancement of Science at: https://doi.org/10.1126/scisignal.aba1302
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