Journal article
Antibody side chain conformations are position-dependent
- Abstract:
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Side chain prediction is an integral component of computational antibody design and structure prediction. Current antibody modelling tools use backbone-dependent rotamer libraries with conformations taken from general proteins. Here we present our antibody-specific rotamer library, where rotamers are binned according to their IMGT position, rather than their local backbone geometry. We find that for some amino acid types at certain positions, only a restricted number of side chain conformatio...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
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(Accepted manuscript, pdf, 1.7MB)
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- Publisher copy:
- 10.1002/prot.25453
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Authors
Funding
+ Engineering and Physical Sciences Research Council
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Funding agency for:
Leem, J
Grant:
EP/L016044/1
+ Engineering and Physical Sciences Research Council
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Funding agency for:
Deane, C
Grant:
EP/L016044/1
UCB Pharma
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Proteins Journal website
- Volume:
- 86
- Issue:
- 4
- Pages:
- 383-392
- Publication date:
- 2018-01-10
- Acceptance date:
- 2018-01-05
- DOI:
- EISSN:
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1097-0134
- ISSN:
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0887-3585
- Pmid:
-
29318667
- Source identifiers:
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817678
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:817678
- UUID:
-
uuid:8b768ec8-ce50-4b7f-8f1e-036c08777169
- Local pid:
- pubs:817678
- Deposit date:
- 2018-01-17
Terms of use
- Copyright holder:
- Wiley Periodicals, Inc
- Copyright date:
- 2018
- Notes:
- © 2018 Wiley Periodicals, Inc. This is the author accepted manuscript following peer review version of the article. The final version is available online from Wiley at: 10.1002/prot.25453
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