- Abstract:
-
Physiology and behaviour are critically dependent on circadian regulation via a core set of clock genes, dysregulation of which leads to metabolic and sleep disturbances. Metabolic and sleep perturbations occur in spinal muscular atrophy (SMA), a neuromuscular disorder caused by loss of the survival motor neuron (SMN) protein and characterised by motor neuron loss and muscle atrophy. We therefore investigated the expression of circadian rhythm genes in various metabolic tissues and spinal cor...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 8.2MB)
-
- Publisher copy:
- 10.1093/hmg/ddy249
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Human Molecular Genetics Journal website
- Volume:
- 27
- Issue:
- 20
- Pages:
- 3582–3597
- Publication date:
- 2018-07-04
- Acceptance date:
- 2018-06-29
- DOI:
- EISSN:
-
1460-2083
- ISSN:
-
0964-6906
- Pubs id:
-
pubs:869317
- URN:
-
uri:8b5f80a8-aac2-49c0-9704-e153c9df4681
- UUID:
-
uuid:8b5f80a8-aac2-49c0-9704-e153c9df4681
- Local pid:
- pubs:869317
- Language:
- English
- Keywords:
- Copyright holder:
- Bowerman et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- License:
- CC BY
Journal article
Light modulation ameliorates expression of circadian genes and disease progression in spinal muscular atrophy mice
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Authors
Funding
SMA Trust
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SMA Angels Charity
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French Muscular Dystrophy Association
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Erasmus+
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Muscular Dystrophy UK
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