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Journal article

Light modulation ameliorates expression of circadian genes and disease progression in spinal muscular atrophy mice

Abstract:

Physiology and behaviour are critically dependent on circadian regulation via a core set of clock genes, dysregulation of which leads to metabolic and sleep disturbances. Metabolic and sleep perturbations occur in spinal muscular atrophy (SMA), a neuromuscular disorder caused by loss of the survival motor neuron (SMN) protein and characterised by motor neuron loss and muscle atrophy. We therefore investigated the expression of circadian rhythm genes in various metabolic tissues and spinal cor...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/hmg/ddy249

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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SMA Angels Charity More from this funder
French Muscular Dystrophy Association More from this funder
Muscular Dystrophy UK More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
27
Issue:
20
Pages:
3582–3597
Publication date:
2018-07-04
Acceptance date:
2018-06-29
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pubs id:
pubs:869317
URN:
uri:8b5f80a8-aac2-49c0-9704-e153c9df4681
UUID:
uuid:8b5f80a8-aac2-49c0-9704-e153c9df4681
Local pid:
pubs:869317
Language:
English
Keywords:

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