Journal article
Rhomboids, signalling and cell biology
- Abstract:
- Here, I take a somewhat personal perspective on signalling control, focusing on the rhomboid-like superfamily of proteins that my group has worked on for almost 20 years. As well as describing some of the key and recent advances, I attempt to draw out signalling themes that emerge. One important message is that the genetic and biochemical perspective on signalling has tended to underplay the importance of cell biology. There is clear evidence that signalling pathways exploit the control of intracellular trafficking, protein quality control and degradation and other cell biological phenomena, as important regulatory opportunities.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Preview, Accepted manuscript, pdf, 195.6KB, Terms of use)
-
- Publisher copy:
- 10.1042/BST20160035
Authors
- Publisher:
- Portland Press
- Journal:
- Biochemical Society Transactions More from this journal
- Volume:
- 44
- Issue:
- 3
- Pages:
- 945-950
- Publication date:
- 2016-06-09
- Acceptance date:
- 2016-02-18
- DOI:
- EISSN:
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1470-8752
- ISSN:
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0300-5127
- Keywords:
- Pubs id:
-
pubs:604998
- UUID:
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uuid:8b598540-62a0-44d4-a286-37843807cfb0
- Local pid:
-
pubs:604998
- Source identifiers:
-
604998
- Deposit date:
-
2016-02-18
- ARK identifier:
Terms of use
- Copyright holder:
- Freeman, M
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 The Author. Published by Portland Press Limited on behalf of the Biochemical Society. This is the accepted manuscript version of the article. The final version is available online from Portland Press at: https://doi.org/10.1042/BST20160035
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