Journal article
A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models
- Abstract:
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Molecular magnetic resonance imaging (MRI) allows visualization of biological processes at the molecular level. Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in neurological disease. The aim of this study, therefore, was to develop a novel molecular MRI contrast agent, by conjugating anti-ALCAM antibodies to microparticles of iron oxide (MPIO), for detection of endothelial ALCAM expression in vivo. Binding specificity...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 1.7MB)
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- Publisher copy:
- 10.1177/0271678x20968943
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Authors
Funding
Bibliographic Details
- Publisher:
- SAGE Publications Publisher's website
- Journal:
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Journal website
- Volume:
- 41
- Issue:
- 7
- Pages:
- 1592-1607
- Place of publication:
- United States
- Publication date:
- 2020-11-05
- Acceptance date:
- 2020-09-18
- DOI:
- EISSN:
-
1559-7016
- ISSN:
-
0271-678X
- Pmid:
-
33153376
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1140976
- Local pid:
- pubs:1140976
- Deposit date:
- 2020-11-23
Terms of use
- Copyright holder:
- Zarghami et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- Licence:
- CC Attribution (CC BY)
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