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Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR

Abstract:

OBJECTIVES:To enhance detection of the products of hyperpolarized [2-13C]dihydroxyacetone metabolism for assessment of three metabolic pathways in the liver in vivo. Hyperpolarized [2-13C]DHAc emerged as a promising substrate to follow gluconeogenesis, glycolysis and the glycerol pathways. However, the use of [2-13C]DHAc in vivo has not taken off because (i) the chemical shift range of [2-13C]DHAc and its metabolic products span over 144 ppm, and (ii) 1H decoupling is required to increas...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-5076-8526
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0002-6258-1299
Publisher:
Springer
Journal:
Magnetic Resonance Materials in Physics, Biology and Medicine More from this journal
Volume:
34
Pages:
49-56
Publication date:
2020-09-10
Acceptance date:
2020-08-27
DOI:
EISSN:
1352-8661
ISSN:
0968-5243
Pmid:
32910316
Language:
English
Keywords:
Pubs id:
1132011
Local pid:
pubs:1132011
Deposit date:
2020-11-25

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