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A new model of temporary focal neocortical ischemia in the rat.

Abstract:

BACKGROUND AND PURPOSE: We describe a new rat model of temporary focal ischemia that produces neocortical ischemia without the need for prolonged anesthesia. METHODS: Temporary focal cerebral ischemia was initiated during halothane anesthesia, maintained for varying periods without anesthesia, and reversed by clip removal requiring brief anesthesia. Tandem carotid and middle cerebral artery occlusion for 1-4 hours and permanent occlusion were used to determine the duration and extent of ische...

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Publication status:
Published

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Publisher copy:
10.1161/01.str.23.2.273

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Journal:
Stroke; a journal of cerebral circulation
Volume:
23
Issue:
2
Pages:
273-279
Publication date:
1992-02-05
DOI:
EISSN:
1524-4628
ISSN:
0039-2499
URN:
uuid:8ac17847-0759-41ac-86b8-6e2fd7bf343c
Source identifiers:
80204
Local pid:
pubs:80204

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