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Greater CD8+ TCR heterogeneity and functional flexibility in HIV-2 compared to HIV-1 infection.

Abstract:

Virus-specific CD8(+) T cells are known to play an important role in the control of HIV infection. In this study we investigated whether there may be qualitative differences in the CD8(+) T cell response in HIV-1- and HIV-2-infected individuals that contribute to the relatively efficient control of the latter infection. A molecular comparison of global TCR heterogeneity showed a more oligoclonal pattern of CD8 cells in HIV-1- than HIV-2-infected patients. This was reflected in restricted and ...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.171.1.307

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Journal:
Journal of Immunology
Volume:
171
Issue:
1
Pages:
307-316
Publication date:
2003-07-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
22888

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