- Abstract:
-
Virus-specific CD8(+) T cells are known to play an important role in the control of HIV infection. In this study we investigated whether there may be qualitative differences in the CD8(+) T cell response in HIV-1- and HIV-2-infected individuals that contribute to the relatively efficient control of the latter infection. A molecular comparison of global TCR heterogeneity showed a more oligoclonal pattern of CD8 cells in HIV-1- than HIV-2-infected patients. This was reflected in restricted and ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.171.1.307
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 171
- Issue:
- 1
- Pages:
- 307-316
- Publication date:
- 2003-07-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:8abfb33b-68b9-4cd0-8133-199b4c312dbe
- Source identifiers:
-
22888
- Local pid:
- pubs:22888
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Greater CD8+ TCR heterogeneity and functional flexibility in HIV-2 compared to HIV-1 infection.
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