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Defining falciparum-malaria-attributable severe febrile illness in moderate-to-high transmission settings on the basis of plasma PfHRP2 concentration.

Abstract:

BACKGROUND: In malaria-endemic settings, asymptomatic parasitemia complicates the diagnosis of malaria. Histidine-rich protein 2 (HRP2) is produced by Plasmodium falciparum, and its plasma concentration reflects the total body parasite burden. We aimed to define the malaria-attributable fraction of severe febrile illness, using the distributions of plasma P. falciparum HRP2 (PfHRP2) concentrations from parasitemic children with different clinical presentations. METHODS: Plasma samples were co...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jis675

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
The Journal of infectious diseases
Volume:
207
Issue:
2
Pages:
351-361
Publication date:
2013-01-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:8abf4e4b-a096-43f6-bfc5-d80e4666fa87
Source identifiers:
358074
Local pid:
pubs:358074

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