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Thesis

RNA-based therapeutics for Alzheimer's disease

Abstract:

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterised pathologically by the accumulation of amyloid-β plaques and neurofibrillary tangles within the brain. Currently, there are no disease-modifying therapeutic interventions available. This thesis describes the development and delivery of novel RNA-based therapeutics for AD.

Recently, significant advances have occurred in the field of RNA interference (RNAi)-based therapeutics, allowing targeted silencing...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:8abb9f7b-9e49-4063-8395-83a57e9b14f7
Deposit date:
2015-11-08

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