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Journal article

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses

Abstract:

A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. Notably, PTPN22 negatively regulates kinases downstream of T-cell receptor (TCR) and LFA-1, thereby setting thresholds for T-cell activation. Alterations to the quality of TCR and LFA-1 engagement at the immune synapse and t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Name:
Wellcome Trust
Funding agency for:
Dustin, M
Grant:
Principal Research Fellowship: 100262
Publisher:
Elsevier
Journal:
Journal of Autoimmunity More from this journal
Volume:
94
Pages:
45-55
Publication date:
2018-07-24
Acceptance date:
2018-07-13
DOI:
EISSN:
1095-9157
ISSN:
0896-8411
Keywords:
Pubs id:
pubs:890249
UUID:
uuid:8ab94148-ba67-473c-b2b7-6068a4211310
Local pid:
pubs:890249
Source identifiers:
890249
Deposit date:
2018-07-23

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