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All-optical control of cardiac excitation: Combined high-resolution optogenetic actuation and optical mapping.

Abstract:

Cardiac tissue is an excitable system that can support complex spatiotemporal dynamics, including instabilities (arrhythmias) with lethal consequences. While over the last two decades optical mapping of excitation (voltage and calcium dynamics) has facilitated the detailed characterization of such arrhythmia events, until recently, no precise tools existed to actively interrogate cardiac dynamics in space and time. In this work, we discuss the combined use of new methods for space‐ and time‐r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1113/jp271559

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Wiley Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
594
Pages:
2503–2510
Publication date:
2016-04-28
Acceptance date:
2015-12-28
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
600824
Language:
English
Pubs id:
pubs:600824
UUID:
uuid:8aae1131-0707-4a2e-b30a-d8ff83f05ded
Local pid:
pubs:600824
Deposit date:
2016-02-15

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