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Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.

Abstract:

The p38 mitogen-activated protein kinase (MAPK) signaling pathway, acting through the downstream kinase MK2, regulates the stability of many proinflammatory mRNAs that contain adenosine/uridine-rich elements (AREs). It is thought to do this by modulating the expression or activity of ARE-binding proteins that regulate mRNA turnover. MK2 phosphorylates the ARE-binding and mRNA-destabilizing protein tristetraprolin (TTP) at serines 52 and 178. Here we show that the p38 MAPK pathway regulates th...

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Publication status:
Published

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Journal:
Molecular and cellular biology
Volume:
26
Issue:
6
Pages:
2408-2418
Publication date:
2006-03-01
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
Source identifiers:
226489

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