Immune cell-specific smoking-related expression characteristics are revealed by re-analysis of transcriptomes from the CEDAR cohort

Journal article

Introduction: Smoking is known to affect whole-blood expression and methylation profiles. Although whole-genome methylation studies indicated that effects observed in blood may be driven by changes within leukocyte subtypes, these phenomena have not been explored using expression profiling. Material and methods: cells were processed. Differential expression analyses were conducted in each immune cell type, followed by gene ontology analysis and supplementary investigations. Results: cells from smokers exhibited overexpression of LDLR and the formyl peptide receptor FPR3. Conclusions: cells.

Authors: Nowak, JK; Dybska, E; Adams, AT; Walkowiak, J

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Termedia Publishing
• Journal: Central European Journal of Immunology
• Volume: 47
• Issue: 3
• Pages: 246-259
• Publication date: 2022-11-16
• DOI: 10.5114/ceji.2022.120618
• EISSN: 1644-4124
• ISSN: 1426-3912
• Language: English
• Keywords: Gene expression; Genetics; Gene; Expression (computer science); Cohort; Immunology; Medicine; Cell; Immune system; Transcriptome; Biology; Computer science; Pathology